拉米夫定治疗干扰素无应答的儿童慢性乙型肝炎疗效分析

目的 对干扰素治疗无应答的儿童慢性乙型肝炎使用拉米夫定序贯治疗,探讨拉米夫定对儿童慢性乙型肝炎的疗效和安全性.方法 40例干扰素治疗无应答的慢性乙型肝炎患儿,口服拉米夫定每日3 mg/kg体质量,最大量100 mg/d,观察3年；定期检查血清生化学指标、HBV血清标志物、HBV DNA定量变化；并测身高、体质量,记录不...

The efficacy of lamivudine treatment for chronic hepatitis B in children unresponsive to interferon-alpha

Objective To investigate the efficacy and the safty of lamivudine treatment in children with chronic hepatitis B who did not respond to previous interferon-alpha treatment.Methods Lamivudine,3 mg/（kg ？ day）（maximum,100 mg/ day）.was given for 3 years to 40 children,aged 7 to 16 years,with chronic HBV infection who did not respond to previous interferon treatment.Data gathered from medical record review included weight,height,signs and symptoms of hepatitis,alanine aminotransferase（ALT） levels,serologic markers,hepatitis B virus（HBV） DNA levels and serious adverse events（SAEs）.Results At the end of 3 year,16 of 20（40%） patient had sustained undetectable HBV DNA and HBV DNA declined by 35%.HBeAg/anti-HBe seroconversion was achieved in 25%and ALT normalization has also been observed at the end of therapy.Evaluation of safety data revealed no SAEs related to lamivudine.Conclusion The treatment of lamivudine for children with chronic hepatitis B after failure of interferon therapy was efficacy and lamivudine could inhibit the HBV replication.Up to 3 years of lamivudine treatment was safe in children.