美罗培南在老年重症感染患者中的应用研究

目的：研究美罗培南延长输注时间和缩短用药间隔在老年重症感染患者中的有效性。方法：入选患者随机分为A、B、c三组。c组为对照组，常规用法，将单次剂量为lg的关罗培南溶于50ml生理盐水以微量泵输注治疗，泵注时间为30min，Q8h；B组延长输注时间并缩短用药间隔（单次剂量750mg），输注时间改为60min，Q6h；A组仅延长输注时间，输注时间改为60rain，Q8h。三组用药剂量均为3g。结果：三组患者中B组有效率显著高于c组，结果差异有统计学意义（P〈0．05）。A组相对c组，其无效率显著低于后者，结果差异有统计学意义。结论：关罗培南在保证给药剂量不变的前提下，缩短用药间隔和延长输注时间能提高重症医学科（ICU）老年重症感染患者的感染控制有效率，值得临床推广。

Appli cation of mevopenem in severe cases of infection among elderly patients

Objective：To evaluate the efficacy of meropenem used with longer infusion time with or without shorter intervals in severe cases of infection among elderly patients. Methods： All eligible patients were randomized into groups A, B and C. The group C （control group ） received 1 g meropenem in 50ml normal saline, infused intravenously through a micro-pump within 30 minutes every 8 hours; group B received 750 mg meropenem infused within a longer duration （60 minutes） with shorter intervals apart （every 6 hours） ; group A received lg Meropenem within a prolong duration （60 minutes） every 8 hours. The total dose was 3g for each group. Results： The group B showed higher rate of response than did the group C （ P 〈 0.05 ）. The rate of non- response was significantly lower in group A than in group C （ P 〈 0.05 ）. Conclusion ： With given total dose, meropenem infused within longer duration and with shorter intervals apart can lead to higher efficacy of disease control in severe cases of infection among elderly patients in wards of critical care medicine.