| RYBP在急性白血病中的表达 |
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| 引用本文： | 钟雯婷,王顺清,张玉平,许艳丽,应逸. RYBP在急性白血病中的表达[J]. 实用医学杂志, 2011, 27(18): 3301-3303. DOI: 10.3969/j.issn.1006-5725.2011.18.015 |
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| 作者姓名： | 钟雯婷 王顺清 张玉平 许艳丽 应逸 |
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| 作者单位： | 广州医学院附属广州市第一人民医院血液科,510180 |
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| 基金项目： | 国家自然科学基金资助项目，广州市医药卫生科技重点资助项目，广州市留学人员专项资金资助项目 |
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| 摘 要： | 目的:观察RYBP(Ring1 and YY1-binding protein)在急性白血病中的表达情况,初步探索其在急性白血病中的临床意义。方法:应用蛋白质免疫印迹(western blot)技术分别检测急性单核细胞白血病细胞株SHI-1、急性早幼粒白血病细胞株HL-60、慢性粒细胞白血病细胞株K562、51例初治急性白血病(AL)患者、23例急性白血病完全缓解(ALCR)患者和21例对照(非恶性血液病)患者骨髓单个核细胞中RYBP的表达情况。结果:SHI-1、HL-60及K562细胞株RYBP表达均为强阳性;21例阴性对照中RYBP表达均为阴性。AL组RYBP表达阳性率为73%,ALCR组阳性率为13%,AL组RYBP表达阳性率及表达量比ALCR组及对照组明显增高(P<0.05)。结论:RYBP在急性白血病细胞中表达水平异常增高,提示RYBP可能与急性白血病密切相关。
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| 关 键 词： | 白血病 Ring1和YY1结合蛋白(RYBP) 蛋白质免疫印迹 |
Expression of RYBP in Acute Leukemia |
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| ZHONG Wen-ting,WANG Shun-qing,ZHANG Yu-ping,XU Yan-li,YING Yi. Expression of RYBP in Acute Leukemia[J]. The Journal of Practical Medicine, 2011, 27(18): 3301-3303. DOI: 10.3969/j.issn.1006-5725.2011.18.015 |
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| Authors: | ZHONG Wen-ting WANG Shun-qing ZHANG Yu-ping XU Yan-li YING Yi |
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| Affiliation: | ZHONG Wen-ting,WANG Shun-qing,ZHANG Yu-ping,XU Yan-li,YING Yi,Department of Hematology,the Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou 510180,China |
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| Abstract: | Objective To investigate the expression and its significance of RYBP(Ring1 and YY1-binding protein)in acute leukemia (AL). Methods RYBP level was assessed by Western blot in the bone marrow mononuclear cells (BM-MNCs) of 51 acute leukemia patients (AL), 23 complete remission (ALCR) patients and 21 negative controls, as well as leukemia cell line SHI-1, HL-60 and K562. Results The expression of RYBP was positive in leukemia cell line SHI-1,HL-60 and K562 but negative in 21 negative controls. The RYBP was exp... |
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| Keywords: | Leukemias Ring1 and YY1-binding protein Western blot |
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