| 腺苷后适应对糖尿病急性心肌梗死再灌注的保护作用 |
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| 引用本文： | 王芳,吴红玲,王执兵,凌云.腺苷后适应对糖尿病急性心肌梗死再灌注的保护作用[J].实用医学杂志,2011,27(21):3872-3874. |
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| 作者姓名： | 王芳 吴红玲 王执兵 凌云 |
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| 作者单位： | 广东省深圳市南山区人民医院VIP病房,518052 |
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| 基金项目： | 深圳市南山区卫生科技计划项目基金 |
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| 摘 要： | 目的:观察经皮冠状动脉介入治疗(PCI)术中腺苷后适应对糖尿病急性心肌梗死(AMI)再灌注的保护作用。方法:将84例AMI患者按入选条件分为非糖尿病再灌注组(IR),非糖尿病腺苷后处理组(POST),糖尿病再灌注组(DIR),糖尿病腺苷后处理组(DPOST),糖尿病组按入院时所测糖化血红蛋白(HbA1c)值再分为DIR1(HbA1c<7%)、DIR2(HbA1c≥7%)、DPOST1(HbA1c<7%)、DPOST2(HbA1c≥7%)。POST及DPOST组于支架植入前静滴腺苷,IR及DIR组于支架植入前静滴等量生理盐水。检测PCI术前及术后30min冠脉血浆中的MDA、SOD及PCI术后6、12、24及48h静脉血CM-MB水平。结果:6组患者术后MDA值均较术前升高(P﹤0.01),SOD值均较术前降低(P﹤0.01);POST及DPOST组MDA值比IR及DIR组升高较少(P﹤0.05),SOD值比IR及DIR降低较少(P﹤0.05)。术后POST及DPOST组CK-MB峰值较IR及DIR组降低(P﹤0.05)。结论:糖尿病急性心肌梗死PCI治疗时应用腺苷后处理可以减轻心肌缺血再灌注损伤,起到心肌保护的作用。
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| 关 键 词： | 腺苷 后适应 糖尿病 急性心肌梗死 心肌缺血再灌注损伤 |
Adenosine postconditioning protects against ischemic-reperfused myocardium of acute myocardial infarction with diabetes |
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| WANG Fang,WU Hong-ling,WANG Zhi-bing,LING Yun.Adenosine postconditioning protects against ischemic-reperfused myocardium of acute myocardial infarction with diabetes[J].The Journal of Practical Medicine,2011,27(21):3872-3874. |
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| Authors: | WANG Fang WU Hong-ling WANG Zhi-bing LING Yun |
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| Institution: | WANG Fang,WU Hong-ling,WANG Zhi-bing,LING Yun.Shenzhen Nanshan Hospital,Shenzhen 518052,China |
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| Abstract: | Objective To investigate the protective effect of adenosine postconditioning on ischemic-reperfused myocardium of acute myocardial infarction with diabetes during percutaneous coronary intervention(PCI) .Methods The 84 patients with acute myocardial infarction(AMI) were divided into 6 groups:non-diabetic ischemic-reperfused(IR) group,non-diabetic postconditioning(POST) group,diabetic ischemic-reperfused(DIR) group,diabetic postconditioning(DPOST) group.The diabetic groups were further divided into DIR1(HbA1... |
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| Keywords: | Adenosine Postconditioning Diabetes Acute myocardial infarction Ischemic-reperfused myocardial injury |
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