Effect of afobazole on teratogenic activity of cyclophosphamide in rats |
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| Authors: | O. V. Shreder N. M. Smolnikova A. D. Durnev S. B. Seredenin |
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| Affiliation: | (1) V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia |
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| Abstract: | A new anxiolytic afobazole (1–100 mg/kg perorally, Russia) dose-dependently abolished the embryotoxic and teratogenic effects of cyclophosphamide and reduced the range of induced malformations in outbred albino rats. Our results suggest that afobazole possesses antiteratogenic activity. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 4, pp. 414–417, April, 2008 |
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| Keywords: | teratogenesis rats cyclophosphamide afobazole |
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