| 食管癌放化疗中血清血管内皮生长因子连续检测及其临床意义 |
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| 引用本文： | 王坚,汪建林,于静萍,孙志强,孙威,聂斌,倪新初,孙苏平,吴昌平.食管癌放化疗中血清血管内皮生长因子连续检测及其临床意义[J].中华放射医学与防护杂志,2016,36(4):278-282. |
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| 作者姓名： | 王坚 汪建林 于静萍 孙志强 孙威 聂斌 倪新初 孙苏平 吴昌平 |
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| 作者单位： | 213003 苏州大学附属第三医院肿瘤生物诊疗中心,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 苏州大学附属第三医院肿瘤生物诊疗中心 |
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| 基金项目： | 江苏省卫生厅指导性科研项目(Z201220) |
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| 摘 要： | 目的 观察食管癌患者放化疗中血清血管内皮生长因子(VEGF)的变化规律,探讨其与预后的关系。方法 回顾性收集76例行根治性放疗的食管癌患者,其中53例行同期化疗,23例行单纯根治性放疗;放疗前、放疗中每周、放疗后1周内连续采集患者血清并测定VEGF水平,VEGF的变化分为上升组、不变组和下降组。另采集30例健康体检者血清并检测其VEGF水平为健康对照组。结果 全组患者1年总生存(OS)率、1年无进展生存(PFS)率分别为55.7%、51.4%,中位OS和PFS分别为13.4和12.5个月,复发13例。放疗中患者血清VEGF水平与放疗前比较呈逐渐下降趋势,差异有统计学意义(F=6.806,P=0.001);患者各时间点VEGF水平均高于健康对照组,差异均有统计学意义(t=2.165~3.896,P<0.05)。上升组、不变组和下降组1年OS率、1年PFS率比较,差异有统计学意义(χ2=6.811、6.602,P<0.05);3组患者局部控制(LC)率比较,差异无统计学意义(P>0.05)。OS、PFS、LC与放疗前血清VEGF无相关关系(r=-0.033、-0.056、0.090,P>0.05)。19例患者血清VEGF较放疗前升高,升高时间大多在放疗第2、3周或放疗后。结论 放化疗过程中血清VEGF变化可预测食管癌患者预后,放疗第2、3周和放疗后1周内检测可能对指导临床个体化治疗有重要意义。
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| 关 键 词： | 食管癌 放化疗 血管内皮生长因子 预后 |
| 收稿时间： | 1/4/2016 12:00:00 AM |
Clinical significance of continuous detection of VEGF in patients undergoing chemoradiotherapy for esophageal carcinoma |
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| Wang Jian,Wang Jianlin,Yu Jingping,Sun Zhiqiang,Sun Wei,Nie Bin,Ni Xinchu,Sun Suping and Wu Changping.Clinical significance of continuous detection of VEGF in patients undergoing chemoradiotherapy for esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2016,36(4):278-282. |
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| Authors: | Wang Jian Wang Jianlin Yu Jingping Sun Zhiqiang Sun Wei Nie Bin Ni Xinchu Sun Suping and Wu Changping |
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| Institution: | Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochou University, Changzhou 213003, China,Department of Radiotherapy, Changzhou Second People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Changzhou Second People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Changzhou Second People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Changzhou Second People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Changzhou Second People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Changzhou Second People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Changzhou Second People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China and Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochou University, Changzhou 213003, China |
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| Abstract: | |
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| Keywords: | Esophageal carcinoma Chemoradiotherapy Vascular endothelial growth factor Prognosis |
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