| 乌梅肉提取物抗腹泻作用研究 |
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| 引用本文： | 王小婷,蒋国政,王海滨,王凤霞,李艳华,盛尊来.乌梅肉提取物抗腹泻作用研究[J].中国现代应用药学,2016,33(4):407-410. |
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| 作者姓名： | 王小婷 蒋国政 王海滨 王凤霞 李艳华 盛尊来 |
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| 作者单位： | 东北农业大学动物医学学院，哈尔滨 150030,东北农业大学动物医学学院，哈尔滨 150030,东北农业大学动物医学学院，哈尔滨 150030,东北农业大学动物医学学院，哈尔滨 150030,东北农业大学动物医学学院，哈尔滨 150030,东北农业大学动物医学学院，哈尔滨 150030 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目(12531047) |
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| 摘 要： | 目的 研究乌梅提取物抗腹泻作用，为临床应用提供依据。方法 通过蓖麻油致小鼠腹泻模型、小肠炭墨推进实验、大鼠肠腔积液实验，以腹泻抑制率、小肠推进率、肠腔积液体积为指标，研究乌梅提取物的抗腹泻作用。结果 乌梅水提物及水提醇沉提取物均具有抗腹泻作用，其中水提醇沉提取物的活性明显高于水提物(P<0.05)，显著抑制正常小鼠的小肠推进运动(P<0.05或0.01)，但对肠腔积液作用不显著。结论 乌梅提取物具有一定的抗腹泻作用，其抗腹泻机制可能与抑制小肠运动有关。
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| 关 键 词： | 腹泻 乌梅 腹泻抑制率 小肠推进率 肠腔积液 |
| 收稿时间： | 2015/8/19 0:00:00 |
| 修稿时间： | 2015/11/12 0:00:00 |
Experimental Study on Anti-diarrheal Activity of Pulp of Mume Fructus Extraction |
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| WANG Xiaoting,JIANG Guozheng,WANG Haibin,WANG Fengxi,LI Yanhua and SHENG Zunlai.Experimental Study on Anti-diarrheal Activity of Pulp of Mume Fructus Extraction[J].The Chinese Journal of Modern Applied Pharmacy,2016,33(4):407-410. |
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| Authors: | WANG Xiaoting JIANG Guozheng WANG Haibin WANG Fengxi LI Yanhua and SHENG Zunlai |
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| Institution: | College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China,College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China,College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China,College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China,College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China and College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China |
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| Abstract: | OBJECTIVE To study the anti-diarrheal activity of Pulp of Mume Fructus extraction. METHODS Anti-diarrheal activity of Mume Fructus extraction was evaluated using castor oil-induced diarrhea, charcoal meal transit and castor oil-induced enteropooling in different group mice or rats. RESULTS Mume Fructus extraction and its preliminary purified extraction both possessed anti-diarrheal property in mice and the latter was superior to the former. Although the preliminary purified extraction did not decreased the volume of castor oil-induced intestinal fluid secretion, it caused a dose-dependent decrease of gastrointestinal transit (P<0.05). CONCLUSION The findings of this study indicate that Mume Fructus extraction possesses anti-diarrhoeal property that related with decreasing gastrointestinal transit. |
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| Keywords: | diarrhea Mume Fructus inhibition rate of diarrhea charcoal meal transit rate enteropooling |
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