生脉注射液对裸鼠人胃癌SGC7901/VCR细胞移植瘤生长及P-gp表达的影响

目的 观察生脉注射液对裸鼠人胃癌SGC7901/VCR细胞移植瘤生长及P-gP表达的影响.方法 建立裸鼠人胃癌SGC7901/VCR细胞皮下移植瘤模型,将裸鼠随机分为生理盐水组、5-FU组、5-FU 异搏定组、5-FU 生脉组、生脉组,观察裸鼠生长状态,计算移植瘤平均瘤重及抑瘤率,检测P-gP表达.结果 5-FU TG生脉组瘤重、瘤体积与生理盐水组、5-FU组、生脉比较,P<0.05,均有统计学意义;抑瘤率(57.96%)明显高于5-FU组(11.66%);5-FU 生脉组瘤重与5-FU 异搏定组比较有统汁学意义(P<0.05),抑瘤率(57.96%)高于5-FU 异搏定组(27.56%).5-FU 生脉组P-gp表达与生理盐水组、5-FU组、生脉组比较,P<0.05,均有统计学意义;5-FU 生脉组与5-Fu 异搏定组比较,P>0.05,无统计学意义;单药生脉组与生理盐水组比较,P<0.05,有统计学意义.结论 以上实验结果表明生脉注射液能抑制裸鼠人胃癌SGC7901/VCR细胞移植瘤生长,降低P-gP表达.

Effects of Shengmai Injection on Tumor Growth and the Expression of P - gp in Transplanted Tumor of Human Gastric Carcinoma of SGC7901/VCR Cell in Nude Mice

Objective To explore the effects of Shengmai Injection on tumor growth and the expression of P-gp in transplanted tumor of human gastric carcinoma of SGC7901/VCR cell in nude mice.Methods Transplanted tumor model of human gastric carcinoma of SGC7901/VCR cell in nude mice was built, which was divided randomly into five groups: normal saline control-group, 5-FU group, 5-FU + verapamil group, 5-FU +Shengmai group, Shengmai group. Nude mice growth state was observed, average weigh and inhibition rate of transp...