| IRBP免疫鼠血清特异性抗体的测定及动态变化 |
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| 引用本文： | 杨培增,毛文书.IRBP免疫鼠血清特异性抗体的测定及动态变化[J].眼科学报,1991,7(2):54-57. |
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| 作者姓名： | 杨培增 毛文书 |
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| 作者单位： | 中山医科大学中山眼科中心，中山医科大学中山眼科中心，中山医科大学中山眼科中心，中山医科大学中山眼科中心，中山医科大学中山眼科中心，中山医科大学中山眼科中心，中山医科大学中山眼科中心，中山医科大学中山眼科中心 |
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| 摘 要： | 我们首次在国内提纯了光感受器间维生素 A类结合蛋白(interphotoreceptor retinoid-binding protein,IRBP),将其免疫 Lewis 大鼠后动态测定了鼠血清抗IRBP 抗体和抗视网膜 S 抗原抗体.发现抗 IRBP 抗体于免疫后第7天出现,以后逐渐上升,于第26天达高峰,未测出抗 S 抗原抗体.根据特异性抗体与实验性自身免疫性葡萄膜视网膜炎(experimental autoimmune uveoretinitis,EAU)之间的关系,讨论了特异性体液免疫反应在 EAU发生中的作用.
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| 关 键 词： | 葡萄膜视网膜炎 自身免疫 IRBP 特异性抗体 |
Longitudinal changes of serum specific antibodies in Lewis rats immunized with IRBP] |
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| P Yang,W Mao,S Li,C Xie,S Pan,X Cao,S Liang,X Huang.Longitudinal changes of serum specific antibodies in Lewis rats immunized with IRBP][J].Eye Science,1991,7(2):54-57. |
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| Authors: | P Yang W Mao S Li C Xie S Pan X Cao S Liang X Huang |
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| Institution: | Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, China. |
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| Abstract: | The serum antibodies specific to either interphotoreceptor retinoid-binding protein (IRBP) or retinal S-antigen were longitudinally determined in Lewis rats immunized with 50 x 10(-6)g of IRBP emulsified with complete Freund's adjuvant. To our knowledge, it is the first time to purify IRBP and to address the experiment with IRBP in China. It was shown that the antibody specific to IRBP appeared on the 7th day, followed by a gradual increase, and reached its peak on the 26th day after immunization. No antibody specific to S-antigen was found. The relation between anti-IRBP antibody and experimental autoimmune uveoretinitis (EAU) which occurred in the increasing phase of the antibody suggests that the humoral immunity may be implicated in the pathogenesis of EAU. |
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