三苯氧胺对乳腺癌术后子宫内膜病变的影响

目的：观察乳腺癌患者术后长期服用三苯氧胺对子宫内膜病变的影响。方法：回顾性分析2002年1月至2004年6月166例乳腺癌患者手术后临床资料。其中102例为雌孕激素受体阳性者，并接受三苯氧胺内分泌治疗作为研究组；其余64例为雌孕激素受体阴性者，未接受三苯氧胺治疗作为对照组。所有患者定期复查阴道超声，发现子宫内膜病变可疑者予官腔镜检查和诊刮活检术。结果：研究组子宫内膜病变发生率为41．18％（42／102），对照组子宫内膜病变发生率为12．50％（8／64），组间差异有统计学意义（P〈0．01）。结论：长期服用三苯氧胺可增加乳腺癌患者术后子宫内膜病变发生率。

Effects of tamoxifen on endometrial lesions in breast cancer patients

Objective To observe the effects of long term use of tamoxifen on endometrial lesions in breast cancer patients. Methods This study retrospectively analyzed the post-operative data of 166 breast cancer patients from January, 2002 to June,2004. The study group included 102 patients who were positive with estrogen and progestogen receptors ,and received tamoxifen treatment. The control group included 64 patients who were negative with estrogen and progestogen receptors,and did not receive tamoxifen treatment. Vaginal B ultrasound was performed periodically in all patients, and hysteroscopy and endometrial pathological biopsy were further performed in the patients with possible endometrial lesions. Results There was a statistically significant difference in the incidence of endometrial lesions between the two group （P〈0.01）,with 41. 18% （42/102） in the study group and 12. 50%（8/64） in the control group, respectively. Conclusion The long-term use of tamoxifen during post-operative period in breast cancer patients can increase the incidence of endometrial lesions.