肿瘤微环境与肿瘤

适宜的微环境可以引起基因组不稳定、提供支架和屏障、产生免疫豁免区域、诱导双向分化和形成许可微环境,促进肿瘤的发生.在肿瘤发展的过程中,肿瘤又形成组织缺氧、pH值降低、营养缺乏和肿瘤血管生成等特点的肿瘤微环境.肿瘤微环境既是肿瘤发生的原因又是肿瘤发展的结果.理解肿瘤微环境在肿瘤发生发展中的作用可能为肿瘤治疗提供新的策略.

Tumor microenvironment and tumor

Rational microenvironment contributes actively to cancer development through multiple mechanisms including triggering genomics instability, providing shield, promoting immune escape, inducing differentiation and permissive nich. Tumorigenesis reversely promotes the form of tumor microenvironment composed of hypoxia, decreasing pH, angiogenesis and nutrition deficiency. Tumor microenvironment not only is the reasons but also results in cancer development and progression. A better understanding of how the tumor environment affects cancer progression would provide the new strategy for cancer therapy.