| 肿瘤坏死因子相关凋亡诱导配体及其受体与肝癌 |
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| 引用本文： | 徐建,李敬东. 肿瘤坏死因子相关凋亡诱导配体及其受体与肝癌[J]. 国际肿瘤学杂志, 2013, 40(8): 605-607 |
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| 作者姓名： | 徐建 李敬东 |
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| 作者单位： | 川北医学院附属医院普外科肝胆胰肠研究所,南充,637000 |
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| 摘 要： | 肿瘤坏死因子相关凋亡诱导配体(TRAIL)及受体能在肝癌细胞中特异性地表达,并通过死亡受体特异性地诱导肿瘤细胞凋亡；TRAIL联合放疗、化疗能有效地克服肿瘤细胞的TRAIL耐受,促进肿瘤细胞凋亡,同时TRAIL的基因治疗在抗肿瘤临床治疗上已得到广泛的应用.
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| 关 键 词： | TNF相关凋亡诱导配体 受体,TNF相关凋亡诱导配体 肝肿瘤 |
Tumor necrosis factor-related apoptosis inducing ligand and its receptors in hepatocellular carcinoma |
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| XU Jian , LI Jing-dong. Tumor necrosis factor-related apoptosis inducing ligand and its receptors in hepatocellular carcinoma[J]. Journal of International Oncology, 2013, 40(8): 605-607 |
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| Authors: | XU Jian LI Jing-dong |
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| Abstract: | Tumor necrosis factor-related apoptosis inducing ligands (TRAIL) and its receptors can specifically express in hepatocellular carcinoma cells. TRAIL can specifically induce tumor cells apoptosis through death receptors (DRs); TRAIL combined radiation and chemotherapy can effectively overcome the TRAIL resistance of tumor cells, and promote the apoptosis of tumor cells, meanwhile the gene therapy of TRAIL on anti-tumor clinical treatment has been widely used. |
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| Keywords: | TNF-related apoptosis-inducing ligand Receptors,TNF-related apoptosis-inducing ligand Liver neoplasms |
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