糖尿病与脂蛋白(a)关系

目的 探讨脂蛋白(a)[LP(a)]与糖尿病(DM)之间的关联.方法 选择江苏省35~74岁多代谢异常和代谢综合征人群,以DM患者作为应变量,将LP(a)四等分作为自变量代入Logistic模型,分别进行单因素和多因素分析.结果 糖尿病的患病率随着LP(a)水平的升高而增加;相关分析显示,LP(a)与甘油三酯(TG)的相关性最强,与低密度脂蛋白胆固醇(LDL-C)的相关性最弱,且除了LDL-C外与其他危险因素的相关系数差异均有统计学意义;在LP(a)与DM的单因素分析中,筛选出差异有统计学意义的指标:年龄、吸烟、血压、TG、载脂蛋白(APO)A/B;代入多因素模型后,LP(a)等分后的第二、三、四组与第一组比较的OR值分别为2.4,2.0和3.7,P<0.001;采用多因素逐步调整Logistic模型分析发现,调整血脂指标后,OR值由6.6降为2.2,但差异仍有统计学意义.结论 LP(a)是糖尿病的独立危险因子,LP(a)与糖尿病(DM)及其微血管病变及心血管并发症有联系.

Study on association between diabetes and lipoprotein(a)

Objective To explore the association of lipoprote in(a)[LP(a)]with diabetes(DM).Methods The study was based on a population of Jiangsu province.The association of LP(a)with DM was analyzed in a cross-sectional study with 2330 subjects aged 35-75 years.Results The prevalence of DM increased with LP(a)leve.lLP(a)corre lated cloesly with trig lyce rides,loosely correlated with low-density lipoprotein cholesterol(LDL-C).No significant association was found between LP(a)and LDL-C.After adjusted for other factors,LP(a)was still significantly associated with DM.After ad justed for lipoproteins,the ORs for DM caused by LP(a)reduced from 6.6 to 2.2(P<0.001).Conclusion LP(a)is an independen trisk factor of DM.LP(a)maybe one of the underlying pathogenic risk factors for DM and its complications.