Creating therapeutic cancer vaccines: notes from the battlefield |
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| Authors: | Overwijk W W Restifo N P |
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| Affiliation: | 1. Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China;2. Institute of Chemistry, University of Silesia in Katowice, 41-500 Chorzów, Poland;1. Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643. E08028, Barcelona, Spain;2. Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona (UB), Av. Diagonal 643. E08028, Barcelona, Spain;2. Department of Otorhinolaryngology - Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland;3. Department of Otorhinolaryngology - Head and Neck Surgery, University of Tampere and Tampere University Hospital, Tampere, Finland;4. Department of Oncology, University of Turku and Turku University Hospital, Turku, Finland;1. Department of Neurology and Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Neurodegenerative Disease Research Center, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China;2. Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, 230026, China;3. Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, 230026, China;4. CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China;5. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China |
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| Abstract: | With the identification of tumor antigens and a knowledge of how to vaccinate against them, the field of tumor immunology faces new challenges. In this article, the authors argue that successful immunotherapies of the future will activate anti-tumor T cells without inducing their anergy or apoptotic death. |
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