培哚普利对轻中度原发性高血压患者血管炎性因子和内皮功能的影响

目的:探讨培哚普利对轻中度原发性高血压(EH)患者血管炎性因子和内皮功能的影响。方法:100例EH患者随机分为培哚普利治疗组(培哚普利组,50例)和常规治疗组(常规组,50例),两组患者在入院后次日凌晨分别空腹采肘静脉血,测定血浆高敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB-C)、内皮素1(ET-1)及一氧化氮(NO)的含量;另选择健康体检者50例作对照组,培哚普利组治疗4周后复查上述指标,与对照组进行比较。结果:培哚普利组和常规组治疗前血浆hs-CRP、FIB-C及ET-1水平较对照组明显增高,NO下降(均P<0.05);治疗4周后,常规组血浆hs-CRP、FIB-C、ET-1与NO水平较治疗前无显著性变化,培哚普利组血浆hs-CRP、FIB-C与ET-1水平均较治疗前下降(均P<0.01),NO升高(P<0.05)。结论:培哚普利可以抑制EH患者血管炎症反应,改善血管内皮功能。

Effects of peridopril on vascular inflammation and vascular endothelium function in patients with mild to moderate essential hypertension

Objective:To explore the effects of peridopril on vascular inflammation and vascular endothelium function in mild-to-moderate essential hypertensive(EH) patients. Method:One hundred EH patients were randomly divided into peridopril group(n=50) and conventional group(n=50).Another 50 healthy people were enrolled as control group.The blood levels of high sensitivity C-reactive protein(hs-CRP),fibrinogen C(FIB-C),endothelium 1(ET-1) and nitric oxide(NO) were measured on the next day after admission and 4 weeks after peridopril tablet treatment(4 mg qd),and we compared the tested indicators among the experimental groups. Result:Compared with control group,the blood levels of hs-CRP,FIB-C and ET-1 increased significantly,while NO decreased significantly in peridopril group and conventional group(all P<0.01).After 4 weeks of treatment,all indicators in conventional group didn’t change significantly,but the serum levels of hs-CRP,FIB-C and ET-1 decreased and NO increased significantly in peridopril group(all P<0.01). Conclusion:Peridopril tablet inhibits the vascular inflammation and protects the vascular endothelium function,which probably plays an important role in prevention of thrombotic diseases in hypertension.