盐酸艾司洛尔预防全麻病人气管内插管致心血管反应的临床观察

目的 观察麻醉诱导的前单次静脉注射的两种剂量的艾司洛尔预防气管插管心血管反应的临床效果及安全性。方法 对２０所医院共１８３０例全麻气管内插管病人于全麻诱导前随机分为静脉注射盐酸艾司洛尔１ｍｇ／ｋｇ组（Ｅ１组）及２ｍｇ／ｋｇ组（Ｅ２组），姐注射生理盐水（Ｅ０组），观察全麻诱导后及插管后１￣１０分钟心率、收缩压、舒张压和平均动脉压变化及不良反应。结果诱导后及插管后Ｅ０组病人心率及平均动脉压明显高于Ｅ１

Bolus administration of esmolol for preventing the haemodynamic response to traccheal intubation:a multicentre clinical study

Objective To explore the dose-response relation and the safety of esmolol administered as a single iv bolus prior to the induction of anesthesia for preventing the haemodynamic response to tracheal intubation.Methods 1830 patients from 20 centres were randomly divided into three groups: E1 group, receiving esmolol at a dose of 1 mg/kg; E2 group, at 2 mg/kg and E0 group, receiving 0.9% NaCl. Heart rate, systolic and diastolic, and mean artery blood pressures (MAP) were measured following the induction and 1 to 10 minutes following the intubation. Results The patients in the E0 group had greater HR and MAP values after anesthesia induction and tracheal intubation than the patients in the E1 and E2 groups (P < 0.05 ~ 0.01 ). The E1 group had higher HR than the E2 group (P < 0.05 ~ 0.01 ). The incidence of tachycardia after intubation was higher in the E0 group (63.8%)than in the E1 group (34.7%) and the E2 group (22.6%) (P< 0.01). The proportion of hypotention and bradycardia was higher in the two treatment groups than the E0 group (P < 0.01), but no severe adverse event was observed. Conclusion A 1 ~ 2 mg/kg bolus of esmolol is effective and safe for preventing the haemodynamic response to tracheal intubation. The clinical and side-effects are all dose-related.