阿尔茨海默病的心理社会危险因素研究

探讨阿尔茨海默病（Ａｌｚｈｅｉｍｅｒｄｉｓｅａｓｅ，ＡＤ）的心理社会危险因素，方法在城市社区中分层整群抽样，１０年间对同一批５５岁及以上人群完成两次二阶段法调查。统计ＡＤ发病率，以Ｌｏｇｉｓｔｉｃ模型分析１０年前的心理社会因素对以后发生ＡＤ的影响作用。结果４８９６名１９８７年时非痴呆时，于１９９７年实访１２０３名。其中按ＤＳＭ－Ⅲ－Ｒ标准诊的发生科研部呆病人１２４例，８１例为符合ＮＩＮＣＤＳ／ＡＤ

Psychosocial risk factors of Alzheimers disease

Objective To explore the relationship between psychosocial factor and risk of Alzheimers disease(AD). Methods A cohort study of people 55 years and older was followed up 10 years after a baseline screening.5 055 elderly subjects in a district of Shanghai were stratified clustering sampled from community. Information about psychosocial factors was collected in 1987. The clinical diagnoses of dementia and AD were made according to DSMR and NINCDSADRDA criteria. 4 896 nondemented persons were followed in 1997. The incidence of AD was calculated and the relationship between the psychosocial factors and the AD was analyzed by Logistic model. Results 1 203 subjects were resurveyed in 1997 and among them 124 new cases of dementia including 81 cases of AD were identified. By computing the relative risk(RR) of psychosocial factors to the AD, many psychosocial factors were found to be correlated with AD including blue collar occupation, no job, no reading or writing, no taking community activities, no gardening in leisure, bad psychological feeling and lower education (RR>1). The items with high PARP>50% were not working, no job, retirement, no taking community activities, no reading or writing, blue collar occupation and no gardening in leisure. MMSE total score is a good predict for AD. Conclusion Psychosocial factors play an important role in the development of Alzheimers disease.