精神分裂症患者认知性电位的检测

目的 探讨精神分裂症患者认知性电位（ＣＥＰ）特征以及治疗缓散后ＣＥＰ变化，方法 应用美国ＣＡ－１０００型电生理仪，建立光和声２种成对刺激方法的关联性负变（ＣＮＶ）以及声，光，触３种刺激方法的长潜时电位（ＡＥＰ，ＶＥＰ，ＳＥＰ），对３１例精神分裂症患者进行ＣＮＶ，ＡＥＰ，ＶＥＰ和ＳＥＰ测定，并对其中２５例患者作了ＣＥＰ随访。结果 患者组与对照组比较，在ＣＮＶ潜伏期Ａ点及ＰＩＮＶ，上明显延迟，分别为（

Cognitive evoked potentials in patients with schizophrenia

Objective To investigate the features of cognitive evoked potentials (CEPs) in schizophrenics and the changes of CEPs between the duration of episode and remission Methods The present study was made with stimuli of auditory, visual, and somatosensory modalities CEPs were recorded from 31 episodical schizophrenics and 25 of them were retested when their clinical symtoms rempitted Results The episodical patients showed significantly longer A latency ( P <0 05) and PINV latency ( P <0 01), and smaller A S 2' area ( P <0 01) Shorter latency was associated with P2 of auditory evoked potential , visual evoked potential and somatosensory evoked potential ( P <0 05), P1 of AEP, N2 of VEP, and N1 of SEP ( P <0 05) Longer latency was associated with P3 of AEP ( P <0 05) Diminished amplitude was associated with N1 P2 of AEP and N1 P2 of VEP, P2 of VEP, and P2 N2 of SEP ( P <0 05) The follow up study revealed that when the psychiatric symptoms remitted, the waveform of CEPs became more steady; amplitude B of CNV, N1 P2 of VEP and P2 N2 of SEP were increased ( P <0 05); the amplitude P2 of AEP and VEP, and P1of AEP were increased into the normal range Conclusion The variations of CEPs are the state marker of schizophrenia