血清瘦素浓度与血压的相关性研究

目的 探讨血清瘦素与高血压，体重指数（ＢＭＩ），能量代谢间的关系。方法 测定６４例男性原发性高血压患者及５４例男性正常血压者的血清瘦素浓度，收缩压（ＳＢＰ）、舒张压（ＤＢＰ）、ＢＭＩ、血糖（Ｇｌｕ）甘油三酯（ＴＧ）总胆固醇（ＴＣ）高密度脂蛋白（ＨＤＬ），低密度脂蛋白（ＬＤＬ）等指标。血清瘦素用放射免疫法测定。分析瘦素与其它各项参数的相关性。结果 （１）两组（１１８例）的血清瘦素浓血压组血清瘦素浓度

Association of serum leptin concentrations with blood pressure

OBJECTIVE: To explore the relationship between serum leptin, hypertension, body mass index (BMI) and energy metabolism. METHODS: Serum leptin concentrations were measured by radioimmunoassay. Blood pressure (BMI) blood sugar (Glu), triglycerides (TG), total cholesterol (TC), LDL, HDL, BUN, Cr and Ur were determined in 64 men with essential hypertension (EHT) and 54 male normotensives (NT). The correlation between leptin and other parameters were analyzed. RESULTS: (1) Serum leptin concentrations n = 118 (3.3 +/- 1.9) micrograms/L in 118 subjects were significantly correlated with SBP, DBP, BMI, Glu, TG, TC and LDL(P < 0.05-P < 0.001). (2) Serum leptin concentrations were strongly correlated with BMI in both EHT and NT groups (P < 0.001). The concentration level was significantly higher in EHT group n = 64 (3.8 +/- 1.9) micrograms/L than in NT group n = 54, (2.8 +/- 1.3) micrograms/L, P < 0.01). The difference in serum leptin concentrations between the two groups disappeared when BMI and age were corrected by analysis of covariance. In NT group, serum leptin concentrations were correlated with SBP (P < 0.05). (3) If the cases of overweight, underweight, hyperglycemia, hyperglyceridemia were excluded, serum leptin concentrations were still highly correlated with BMI, but no longer related to blood pressure. CONCLUSION: Serum leptin concentrations are not directly related to blood pressure, but the concentration levels are actually correlated with the degree of obesity and energy metabolism.