| 血管内皮生长因子在非小细胞肺癌中的表达及其意义 |
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| 引用本文： | Yang G,Zhang L,Xie Y. 血管内皮生长因子在非小细胞肺癌中的表达及其意义[J]. 中华医学杂志, 1999, 0(2): 104-105 |
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| 作者姓名： | Yang G Zhang L Xie Y |
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| 作者单位： | 北京医科大学临床肿瘤学院 |
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| 摘 要： | 探讨血管内皮生长因子在肺癌中的表达及与肿瘤生长转移,预后和新生血管形成的关系。方法对５３例周围型非小细胞肺癌患者,采用免疫组织化学法,进行ＶＥＧＦ抗体标记和肿瘤组织ＶＥＧＦ表达;用Ｆ８因子抗体标记瘤组织的血管生成。
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| 关 键 词： | 肺肿瘤 非小细胞肺癌 血管内皮 生长因子 VEGF |
Vascular endothelial growth factor in non-small cell lung carcinoma expression and its significance |
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| Yang G,Zhang L,Xie Y. Vascular endothelial growth factor in non-small cell lung carcinoma expression and its significance[J]. Zhonghua yi xue za zhi, 1999, 0(2): 104-105 |
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| Authors: | Yang G Zhang L Xie Y |
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| Affiliation: | School of Oncology, Beijing Medical University, Beijing 100036. |
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| Abstract: | OBJECTIVE: To clarify the relationship between the expression of vascular endothelial growth factor (VEGF) and the angiogenesis, invasion, prognostic value in non-small cell lung cancer. METHODS: Immunohistochemistry. RESULTS: 53 patients with NSCLC after radical resection were evaluated. A significantly higher microvessel density (MVD) was observed in the tumors with high expression of VEGF compared with that of the low expression (P < 0.001). 29 patients (80%, 29/33) with the high expression of VEGF showed lymph node metastasis and 4 patients (27%, 4/15) unlymph node metastasis (P < 0.001). By Cox's proportional hazard model analysis, the expression of VEGF was considered an independent predictor for the prognosis of NSCLC. CONCLUSIONS: The expression of VEGF has a significant correlation among MVD, growth, invasion, and lymph node metastasis. The patient with the tumor of the higher expression of VEGF and MVD may have poor prognosis. VEGF may be an independent predictor of prognosis. |
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| Keywords: | Endothelial growth factors Neovascularization Carcinoma non-small cell |
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