| 异丙肾上腺素性心肌缺血大鼠全身重要脏器自由基系统的改变及其意义 |
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| 引用本文： | 董传仁,刘金保,欧阳静萍,涂淑珍,杨海鹭.异丙肾上腺素性心肌缺血大鼠全身重要脏器自由基系统的改变及其意义[J].中国病理生理杂志,1991(6). |
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| 作者姓名： | 董传仁 刘金保 欧阳静萍 涂淑珍 杨海鹭 |
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| 作者单位： | 湖北医学院病理生理教研室，湖北医学院病理生理教研室，湖北医学院病理生理教研室，湖北医学院病理生理教研室，湖北医学院病理生理教研室 广州医学院病生室 |
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| 摘 要： | 本文以异丙肾上腺素性心肌梗塞为模型系统地观察了全身重要脏器及血清脂质过氧化产物丙二醛(MDA)含量及抗氧化酶如超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力的改变。结果表明,心肌缺血大鼠全身重要脏器MDA含量增加,且缺血心肌SOD及GSH-Px活力增强。由此说明,心肌缺血大鼠全身重要脏器均存在着严重的自由基损伤效应,同时抗氧化酶活力亦随之代偿性增强。
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| 关 键 词： | 异丙肾上腺素 心肌梗塞 自由基 |
The changes of oxygen free radicals in isoproterenol-induced myocardial infarction and its significance |
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| Dong Chuan-Ren,Liu Jin-Bao,et al.The changes of oxygen free radicals in isoproterenol-induced myocardial infarction and its significance[J].Chinese Journal of Pathophysiology,1991(6). |
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| Authors: | Dong Chuan-Ren Liu Jin-Bao |
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| Institution: | Dong Chuan-Ren,Liu Jin-Bao,et al Department of Pathophysiology,Hubei Medibal College,Wuhan |
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| Abstract: | The MDA contents, SOD and. GSH-Px activities of the heart, liver, brain, kidney and serum were observed systematically in isoprotercnol-induced myocardial infarction. The results suggested that the MDA contents, SOD and GSH-Px activities were increased in ischemic myocardium. Oxygen free radicals exerted detrimental effects on vitals organs, and also was accompanied by a compensatory increase of SOD and GSH-Px activities. |
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| Keywords: | Isoproterenol Myocardial infarction Free Radicals |
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