Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats |
| |
| Affiliation: | 1. Department of Pharmacogenomics, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan;2. Laboratory of Biochemistry, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Chiba 274-8555, Japan;3. International Plant Biotechnology Outreach, VIB, Technologiepark 122, 9052 Ghent, Belgium;1. Group of Cellular and Molecular Pharmacology, Faculty of Medicine, University of Murcia, Spain;2. IMIB (Institute of Biomedical Investigation of Murcia)-Arrixaca, Murcia, Spain;1. Department of Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran;2. Department of Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran;1. Laboratory of Biochemistry, School of Pharmacy, Nihon University, Narashinodai 7-7-1, Funabashi 274-8555, Japan;2. Laboratory of Molecular Cell Biology, School of Pharmacy, Nihon University, Narashinodai 7-7-1, Funabashi 274-8555, Japan;3. Laboratory of Pharmacology, School of Pharmacy, Nihon University, Narashinodai 7-7-1, Funabashi 274-8555, Japan;4. Laboratory of Physiology and Anatomy, School of Pharmacy, Nihon University, Narashinodai 7-7-1, Funabashi 274-8555, Japan;5. Center for Environment, Health and Field Sciences, Chiba University, Kashiwanoha 6-2-1, Kashiwa 277-0822, Japan;1. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, United States;2. Department of Pharmacology, University of Arizona, Tucson, AZ 85721, United States;1. Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Programa de Pós-graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, RS, Brazil;2. Departamento: Tecnologia e Ciência dos Alimentos, Centro de Ciência Rurais, Programa de Pós-graduação em Ciência e Tecnologia dos Alimentos, Universidade Federal de Santa Maria, RS, Brazil |
| |
| Abstract: | Neurolathyrism is a motor neuron disease that is caused by the overconsumption of grass peas (Lathyrus sativus L.) under stressful conditions. The neuro-excitatory β-N-oxalyl-L-α,β-diaminopropionic acid present in grass peas was proposed the causative agent of spastic paraparesis of the legs. Historical reports of neurolathyrism epidemics, studies of neurolathyrism animal models, and in vitro studies on the mechanism of β-N-oxalyl-L-α,β-diaminopropionic acid toxicity support the hypothesis that stress increases susceptibility to neurolathyrism. To elucidate the role of stress in neurolathyrism-induced motor dysfunction, we focused on the hypothalamic-pituitary-adrenal axis in a rodent model of neurolathyrism. Our results implicated increased glucocorticoid and neuroinflammation in the motor dysfunction (paraparesis) exhibited by the stress loaded rat models of neurolathyrism. |
| |
| Keywords: | Neurolathyrism Hypothalamic-pituitary-adrenal axis β-diaminopropionic acid Stress Paraparesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
