Cadmium: Toxic effects on placental and embryonic development |
| |
| Affiliation: | 1. LR11ES41: Génétique, Biodiversité et Valorisation des Bioressources, Institut de Biotechnologie, Université de Monastir, 5000 Monastir, Tunisia;2. Laboratoire d’Histologie, Cytologie et Génétique (02/UR/08-03), Faculté de Médecine de Monastir, Université de Monastir, Monastir, Tunisia;3. Laboratoire de Biochimie et Toxicologie Environnementale, ISA, Chott-Mariem, 4042 Sousse, Tunisia;1. Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA;2. Department of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA;3. Department of Geology, Dartmouth College, Hanover, NH, USA;1. MOE and Shanghai Key Laboratory of Children''s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3. Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China;1. Department of Medical Laboratory, Hunan University of Medicine, Huaihua 418000, China;2. Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China;1. Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA;2. Department of Epidemiology, University of Washington, Seattle, WA, USA;3. Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA;4. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA;5. Department of Family Medicine & Public Health, University of California San Diego, La Jolla, CA, USA;6. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA |
| |
| Abstract: | Cadmium is a non-essential trace metal that has strong teratogenic and mutagenic effects in living organisms. The content is more highly enriched in women than in men and can enter the embryo through the placenta and destroy the placenta's morphological structure, resulting in fetal growth restriction. In this report, we review published data linking pregnancy exposure to cadmium to placenta and fetal growth and development toxicity and summarize the related mechanisms. An understanding of how cadmium exposure contributes to placental and fetal development is necessary for the development of prevention and control strategies for fetal development defects caused by cadmium exposure during pregnancy. |
| |
| Keywords: | Cadmium Pregnancy Placenta Embryonic development |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
