Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water |
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| Affiliation: | 1. Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;2. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;3. Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico;1. Endocrine Division, Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Universidade Federal do Maranhão, Maranhão, Brazil;3. Cardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil;4. Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;5. Brazilian Society of Cardiology, Brazil;6. Hospital Dante Pazzanese, São Paulo, Brazil;7. Sociedade Hospitalar Angelina Caron, Paraná, Brazil;8. Ambulatorio de Especialidades Maria Zelia, São Paulo, Brazil;9. Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil;10. Hospital Escola Alvaro Alvim, Rio de Janeiro, Brazil;11. Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil;12. Hospital Português, Pernambuco, Brazil;13. Research Institute of Heart Hospital (Hcor), São Paulo, Brazil;14. Heart Institute of University of São Paulo, Brazil;15. Universidade Nove de Julho (UNINOVE), São Paulo, Brazil;p. Hospital da Bahia, Bahia, Brazil;1. Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;2. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;3. Departamento de Epidemiología Clínica y Salud Pública, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;4. Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rioverde, San Luis Potosí, Mexico;1. Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India;2. Health Point Multispecialty Hospital, Kolkata 700025, India;3. Ramakrishna Sarada Mission Matri Bhavan, Kolkata 700026, India;4. Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India;5. Department of Dermatology, West Bank Hospital, Howrah 711109, India;6. Department of Environmental Studies, School of Environmental Studies, Jadavpur University, Kolkata 700032, India;1. The Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China;2. School of Public Health, Qingdao University, Qingdao 266071, China;3. Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China;4. Departments of Environmental Health Sciences & Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY 12144, USA |
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| Abstract: | The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 μg/g creatinine was found after urine samples were analyzed (n = 105). Significant associations between UAs levels and serum expression levels of miR-155 (p < 0.05) and miR-126 (p < 0.05) were observed after adjustment for assessed co-variables. Alterations in the serum expression levels of miR-155 and miR-126 may be associated with the onset and development of cardiovascular diseases, hence miRNAs could be proposed as prognostic CVD biomarkers. Data found in this study are of concern and risk reduction plans are necessary for the assessed communities to prevent cardiovascular events in this population of women. |
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| Keywords: | Arsenic Cardiovascular diseases Epigenetic mechanisms miR-126 miR-155 Mexico |
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