DNA damage and adverse neurological outcomes among garlic farmers exposed to organophosphate pesticides |
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| Affiliation: | 1. Centro Universitário La Salle, Mestrado em Avaliação de Impactos Ambientais, Canoas, RS, Brazil;2. Postgraduate Programme in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;3. Laboratory of Cellular and Molecular Biology, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil;4. Toxicology Institute, Catholic Pontificie University of Rio Grande do Sul, Porto Alegre, RS, Brazil;5. Laboratory of Genetic Toxicology, Postgraduate Programme in Genetic and Applied Toxicology, Lutheran University of Brazil, Canoas, RS, Brazil;1. College of Education, Shanghai Normal University, No. 100 Guilin Road, 200234, Shanghai, China;2. Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, Vossstrasse 4, DE–69115 Heidelberg, Germany |
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| Abstract: | Garlic farmers used organophosphate pesticides to control insects, resulting in an increased risk for adverse health outcomes. Thus, we investigated exposure to organophosphate pesticides, DNA damage, nerve conduction, and neurological symptoms among 134 garlic farmers. They were interviewed, measured nerve conduction, and collected blood and urine for determining DNA damage and dialkylphosphate metabolites. Total dialkylphosphate levels of farmers who began cultivating garlic in October were significantly higher than those of non-farmers and the farmers who began cultivating in November and December. Farmers showed significantly longer comet tail lengths and tail moments than non-farmers. However, their mean compound motor and sensory nerve action potential amplitudes of the median, ulnar, and common peroneal nerves were within normal ranges. Measurement of DNA damage is useful as a biomarker of long-term and low-level exposure to organophosphate pesticides; however, electromyography might be not sufficiently sensitive to detect nerve conduction effects in farmers exposed to pesticides. |
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| Keywords: | Organophosphate Dialkylphosphate DNA damage Nerve conduction Neurological symptom |
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