Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice |
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| Authors: | Fujita Masaki Ye Qing Ouchi Hiroshi Harada Eiji Inoshima Ichiro Kuwano Kazuyoshi Nakanishi Yoichi |
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| Affiliation: | Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812, Japan. fujita@kokyu.med.kyushu-u.ac.jp |
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| Abstract: | The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity. |
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