血清PSA和性激素六项联合检测与前列腺良恶性疾病的关系

为探讨血清前列腺特异性抗原(PSA)、游离前列腺特异性抗原(fPSA)、f/t PSA及性激素六项在前列腺疾病中的应用价值,用放射免疫法(RIA)测定72例前列腺增生(BPH)患者和40例前列腺癌(Pca)患者血清中的PSA、fPSA、f/t PSA及性激素六项[睾酮(T)、孕酮(P)、雌二醇(E2)、垂体泌乳素(PRL)、促黄体生成素(LH)、促卵泡成熟激素(FSH)]水平.结果表明,BPH组的性激素T、E2、PRL、LH、FSH水平均明显低于Pca组,Pca组中P水平明显低于BPH组;BPH组fPSA、f/t PSA比值均明显高于Pca组.提示前列腺良恶性疾病(BPH和Pca)与激素水平失调有关,血清tPSA、fPSA均是诊断Pca和BPH的重要指标,与血清f/t PSA联合测定,可提示哪些患者需要进行前列腺TRUS,并可提高Pca早期检出率.

The Relationship Between Serum PSA, Six Sex Hormones and the Benign or Malignant Prostate Diseases

In order to study clinical significance of serum prostate-specific antigen(PSA),free prostate specific antigen(PSA),f/tPSA and six sex hormones in prostate diseases,the serum levels of PSA,fPSA,f/tPSA,T,P,E2,PRL,LH and FSH in 72 cases of hyperplasia of prostate patients and 40 patients with prostate cancer were determined by RIA.The results showed that the serum levels of T,E2,PRL,LH,FSH in the BPH Group were significantly lower than those of in Pca group,the serum level of P in Pca group were significantly lower than those in BPH group;the levels of fPSA and f/tPSA ratio in BPH Group were significantly higher than those in Pca group.The results suggest that benign and malignant prostate disease(BPH and Pca)was related with the hormone imbalance.The serum total PSA and fPSA can be regarded as important indicators in the diagnosis of BPH and Pca.The combined determination of PSA,fPSA and f/tPSA may improve the diagnostic accuracy of Pca.