81mKr: Production,application, and use of computer for ventilation studies

Theoretical excitation functions have been used for the production of neutron-deficient rubidium isotopes by (, kn) reactions on ⁷⁹Br and ⁸¹Br. Krypton generators have been produced using the internal beam of the cyclotron of the Rudjer Bokovi Institute. New methods for target preparation and radiochemical separation have been developed.Preliminary clinical studies have been performed with the aim of investigating the possible use of krypton generators in conjunction with a gamma camera and a digital computer.The digital computer was used to normalize images of regional ventilation and to calculate and display isoventilation regions.Clinical examples of images of regional ventilation that permit resolution between nonventilated and well-ventilated regions are given.