| 高效液相色谱法测定盐酸左氧氟沙星软膏中主药的含量 |
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| 引用本文： | 邹鲜红,彭韪,肖拥军,朱美容.高效液相色谱法测定盐酸左氧氟沙星软膏中主药的含量[J].中国药房,2005,16(12):946-947. |
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| 作者姓名： | 邹鲜红 彭韪 肖拥军 朱美容 |
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| 作者单位： | 珠海联邦制药股份有限公司,珠海市,519000 |
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| 摘 要： | 目的:建立以高效液相色谱法测定盐酸左氧氟沙星软膏中盐酸左氧氟沙星含量的方法。方法:色谱柱为C18,流动相为0.05mol/L柠檬酸-乙腈(85∶15),检测波长为293nm,流速为1.0ml/min,柱温为40℃,进样量为10μl。结果:盐酸左氧氟沙星检测浓度在3.88～38.78μg/ml范围内线性关系良好(r=0.9998);平均加样回收率为99.4%(n=9)。结论:本方法准确、可靠,能有效控制盐酸左氧氟沙星软膏的质量。
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| 关 键 词： | 高效液相色谱法 盐酸左氧氟沙星 软膏 含量 |
| 文章编号： | 1001-0408(2005)12-0946-02 |
| 修稿时间： | 2005年3月9日 |
Determination of Principal Components in Levofloxacin Hydrochloride Ointment by HPLC |
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| ZOU Xianhong,PENG Wei,Xiao Yongjun,Zhu Meirong.Determination of Principal Components in Levofloxacin Hydrochloride Ointment by HPLC[J].China Pharmacy,2005,16(12):946-947. |
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| Authors: | ZOU Xianhong PENG Wei Xiao Yongjun Zhu Meirong |
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| Abstract: | OBJECTIVE:To establish a HPLC method for the determination of levofloxacin hydrochloride in the levoflo_ xacin hydrochloride ointment.METHODS:The chromatographic column was C 18 ,the mobile phase was consisted of0.05mol/L citric acid-acetonitrile(85∶15)with detection wavelength at293nm and flow speed at1.0ml/min,the column temperature was40℃and the sample size was10μl.RESULTS:Good linear relation was achieved when the levofloxacin hydrochloride concen-tration was at the range of3.88～37.88ug/ml(r=0.9998);The average recovery was99.4%(n=9).CONCLUSION:This determination method is accurate,reliable and it can act as an effective quality control for levofloxacin hydrochloride ointment. |
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| Keywords: | HPLC Levofloxacin hydrochloride Ointment Content determination |
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