微卫星DNA DXS1113的多态性与心境障碍

目的 搜寻中国汉族人Ｘ染色体上的心境障碍（ＭＤ）易患性基因，探讨ＤＮＡＤＸＳ１１１３多态性与ＭＤ的关系及遗传学特征。方法 运用扩增片段长度多态性检测技术，分析８０例ＭＤ患者ＤＸＳ１１１３二核苷酸串联重复序的多态性分布，并以８０名正常人作为对照。结果 在对照组和ＭＤ组中检出１２种ＤＸＳ１１１３多态性片段，ＭＤ组与对照组之间有４种片段的差异有显著性。结论ＤＸＳ１１１３与ＭＤ关联，提示中国汉族人Ｘ染色体

Polymorphisms of microsatellate DNA DXS1113 and mood disorders

Objective Search for a gene predisposing to mood disorders (MD)on chromosome X in the Han nationality of Chinese, to explore the relationship between DXS1113 polymorphism with MD and feature of the genetics Methods The dinucleotide repeat polymorphism distribution of DXS1113 for 80 patients with MD was examined by amplified fragment length polymorphism (Amp FLP) examination technique The control group consisted of 80 unrelated normal Chinese individuals Results There was 12 alleles of DXS1113 among the patient and the normal controls The results of statistical handing showed that four alleles (158 bp, 168 bp, 170 bp, 174 bp) was significant different ( P <0 05) between patient and normal scontrols Conclusion The results of this study demonstrate that the DXS1113 is association with affective disorder in the Hna nationality of Chinese This results suggest that there was a mood disorders liability gene on X chromosome (Xq27 3 q28) in Chinese samples