| 高效液相色谱法测定坎地沙坦酯含量 |
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| 引用本文： | 于治国,王倩,王锋.高效液相色谱法测定坎地沙坦酯含量[J].沈阳药科大学学报,2002,19(2):109-111,117. |
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| 作者姓名： | 于治国 王倩 王锋 |
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| 作者单位： | 沈阳药科大学药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的用高效液相色谱法测定了坎地沙坦酯的含量。方法采用ODS柱 ,流动相为乙腈 水(体积比 80∶2 0 ,磷酸调节 pH值至 3 2 ) ,在波长2 5 2nm检测。结果测定了坎地沙坦酯的含量 ,平均含量为 99 4 % (RSD =0 4 0 % ,n =3) ;样品进样量在 0 5～ 2 5 μg内 ,与峰面积具有良好的线性关系 ,线性回归方程为 :A =-1 0 4 5 + 92 772W ,r =0 9999。结论本测定方法灵敏、准确 ,重现性好 ,适用于坎地沙坦酯及其制剂的常规分析。
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| 关 键 词： | 坎地沙坦酯 高效液相色谱法 含量测定 |
| 文章编号： | 1006-2858(2002)02-0109-03 |
Determination of the content of candesartan cilexetil by HPLC |
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| YU Zhi guo,WANG Qian,WANG Feng.Determination of the content of candesartan cilexetil by HPLC[J].Journal of Shenyang Pharmaceutical University,2002,19(2):109-111,117. |
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| Authors: | YU Zhi guo WANG Qian WANG Feng |
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| Abstract: | Objective To develop a reversed phase high performance liquid chromatographic method to determine the content of candesartan cilexetil. Method The mobile phase consisted of acetonitrile water(80∶20, adjusted to pH 3 2 using phosphoric acid) and the UV absorbance was monitored at 252 nm . Result The average content was 99 4% with RSD=0 40%. Conclusion This assay demonstrated that the method had adequate sensitivity and selectivity to measure the concentrations of candesartan cilexetil and could be used in the quality control of candesartan cilexetil. |
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| Keywords: | candesartan cilexetil RP HPLC determination |
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