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Differentiation of a primitive neuroectodermal tumor into a benign ganglioglioma |
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| Authors: | J Russel Geyer Deborah Schofield Mitchell Berger Jerrold Milstein |
| Institution: | (1) Pediatrics, Children's Hospital & Medical Center, University of Washington, Seattle, Washington, USA;(2) Pathology, Children's Hospital & Medical Center, University of Washington, Seattle, Washington, USA;(3) Neurological Surgery, Children's Hospital & Medical Center, University of Washington, Seattle, Washington, USA;(4) Neurology, Children's Hospital & Medical Center, University of Washington, Seattle, Washington, USA;(5) Hematology/Oncology, Children's Hospital, 4800 Sand Point Way NE, 98105 Seattle, WA, USA |
| Abstract: | We describe a case of cerebellar neuroblastoma with histologic documentation of maturation into a ganglioglioma sixteen months later. Only chemotherapy was administered following the initial surgery and the child is well and disease-free three years following her final surgical procedure. The outcome of this patient supports previous hypotheses that the cerebellar neuroblastoma may be a less malignant tumor than its other primitive neuroectodermal posterior fossa counterparts. Furthermore, this case suggests a role for second-look surgery in the management of selected pediatric brain tumors. |
| Keywords: | cerebellar neuroblastoma primitive neuroectodermal tumor (PNET) computerized tomography (CT) cell differentiation |
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