| 灯盏花素对抗结核药致小鼠肝损伤的影响 |
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| 引用本文： | 杨淑艳,钟秀宏,王爽,温娜,杨宁江. 灯盏花素对抗结核药致小鼠肝损伤的影响[J]. 中国医药导报, 2011, 8(30): 25-26 |
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| 作者姓名： | 杨淑艳 钟秀宏 王爽 温娜 杨宁江 |
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| 作者单位： | 吉林医药学院病理教研室,吉林吉林,132013 |
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| 基金项目： | 吉林省吉林市科技发展计划项目 |
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| 摘 要： | 目的：观察灯盏花素对抗结核药致小鼠肝损伤的影响。方法：采用异烟肼和利福平制造小鼠肝损伤模型，将40只小鼠随机分为对照组、模型组、护肝片组、灯盏花素低剂量组和高剂量组，每组各8只，分别灌胃，每日1次，持续两周。取血，检测谷草转氨酶（AST）水平；取肝，观察肝病理学变化。结果：灯盏花素高剂量组和护肝片组均能明显降低肝损伤小鼠血清AST水平（P〈0．05、P〈0．01）；病理学检查显示，与对照组比较，模型组肝体积增大，颜色变浅，镜下出现严重的肝细胞变性、坏死及炎细胞浸润；与模型组比较，灯盏花素低剂量组肝体积缩小，肝细胞损伤明显减轻；与灯盏花素低剂量组比较，灯盏花素高剂量组肝细胞轻度变性。结论：灯盏花素对抗结核药致小鼠肝损伤具有保护作用。
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| 关 键 词： | 灯盏花素 抗结核药 肝损伤 |
Effect of Breviscapine on hepatic injury induced by anti-tuberculosis drugs in mice |
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| YANG Shuyan,ZHONG Xiuhong,WANG Shuang,WEN Na,YANG Ningjiang. Effect of Breviscapine on hepatic injury induced by anti-tuberculosis drugs in mice[J]. China Medical Herald, 2011, 8(30): 25-26 |
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| Authors: | YANG Shuyan ZHONG Xiuhong WANG Shuang WEN Na YANG Ningjiang |
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| Affiliation: | YANG Shuyan,ZHONG Xiuhong WANG Shuang,WEN Na,YANG Ningjiang Pathological Staff Room,Jilin Medical College,Jilin Province,Jilin 132013,China |
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| Abstract: | Objective:To observe the effect of Breviscapine on hepatic injury in mice induced by anti-tuberculosis drugs.Methods:Isoniazid and Rifampicin were used in mice as model of hepatic injury.40 mice were randomly divided into control group,model group,hugan tables group,low and high dose of Breviscapine groups,each group had 8 rats.Gastric perfusion was administered once a day for two weeks.The level of aspartate transaminase(AST) in serum and the pathology changes of liver were detected.Results:The level of AS... |
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| Keywords: | Breviscapine Anti-tuberculosis drugs Hepatic injury |
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