| Th17细胞在免疫性心肌炎中的作用机制 |
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| 引用本文： | 解玉泉. Th17细胞在免疫性心肌炎中的作用机制[J]. 医学综述, 2011, 17(22): 3361-3364 |
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| 作者姓名： | 解玉泉 |
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| 作者单位： | 复旦大学附属中山医院心内科,上海市心血管病研究所,卫生部病毒性心脏病重点实验室,上海,200032 |
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| 基金项目： | 国家自然科学基金，复旦大学重点学科优秀博士基金 |
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| 摘 要： | 在经典的辅助性T细胞亚群Th1/Th2研究过程中,发现了一种新型的分化发育和功能特征显著不同的辅助性T细胞Th17。Th17细胞的分化发育依赖于局部微环境及特定细胞因子的作用,主要分泌效应分子白细胞介素(IL)17A/F和IL-22、IL-21。目前研究认为Th17与机体抗胞外菌感染和一些自身免疫疾病的关系密切,因此探索Thl7细胞的分化与调控将有助于认识其在抗感染免疫和自身免疫性疾病中的作用机制,也有利于自身免疫性疾病生物学治疗靶点的发现。
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| 关 键 词： | Th17 白细胞介素17 分化发育 免疫性心肌炎 |
The Role of Th17 Cells in the Pathogenesis of Autoimmune Myocarditis |
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| XIE Yu-quan. The Role of Th17 Cells in the Pathogenesis of Autoimmune Myocarditis[J]. Medical Recapitulate, 2011, 17(22): 3361-3364 |
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| Authors: | XIE Yu-quan |
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| Affiliation: | XIE Yu-quan,CHEN Rui-zhen,CHEN Hao-zhu.(Department of Cardiology,Zhongshan Hospital Affiliated to Fudan University,Shanghai Institute of Cardiovascular Diseases,Key Laboratory of Viral Heart Diseases,Ministry of Public Health,Shanghai 200032,China) |
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| Abstract: | T helper cells are classically defined as type 1(Th1)and Th2.Recently,Th17 cells,a newly discovered subset of T cell,is identified according to their ability to produce effector molecules IL-17A/F,IL-22 and IL-21.The differentiation and development of Th17 cells depend on local microenvironment and specific cytokine.Previous studies show that Th17 cells have a close relation to the inflammatory responses and autoimmune diseases.Consequently,in order to explore the differentiations and regulations of Th17 ce... |
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| Keywords: | Th17 Interleukin-17 Differentiation and development Autoimmune myocarditis |
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