| 肿瘤坏死因子超家族成员分子结构的研究进展 |
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| 引用本文： | 熊娟. 肿瘤坏死因子超家族成员分子结构的研究进展[J]. 医学综述, 2011, 17(22): 3407-3409 |
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| 作者姓名： | 熊娟 |
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| 作者单位： | 浙江省肿瘤医院检验科,杭州,310022 |
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| 摘 要： | 肿瘤坏死因子超家族成员(TNFSF)是体内重要的一类细胞因子,其含有共同结构序列——TNF同源结构域(THD),通过THD结构域,TNF配体与富含半胱氨酸结构域(CRDs)的TNF受体相结合。又由于不同分子含有的CRDs数目及类型的不同,使得TNF与TNF-R结合后发挥不同的生物学特点。现对TNF超家族和TNF-R的分子结构的研究进展予以综述。
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| 关 键 词： | 肿瘤坏死因子超家族 肿瘤坏死因子受体 分子结构 |
Research Advances of Molecular Structure of Tumor Necrosis Factor Superfamily |
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| XIONG Juan. Research Advances of Molecular Structure of Tumor Necrosis Factor Superfamily[J]. Medical Recapitulate, 2011, 17(22): 3407-3409 |
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| Authors: | XIONG Juan |
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| Affiliation: | XIONG Juan,XU Xiao-hong.(Department of Laboratory,Zhejiang Cancer Hospital,Hangzhou 310022,China) |
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| Abstract: | As an important type of cytokines,the tumor necrosis factor superfamily（TNFSF）has a common homology of functional domains—TNF homeo domains（THD）.Through specific THD,much biological effect is mediated by TNF ligand connecting with TNF-R cysteine-rich domain.Owing to the difference of the number of TNF-R cysteine-rich domain and categorization,the biological features are various.Here is to discuss the molecular structure of TNFSF and TNF-R. |
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| Keywords: | Tumor necrosis factor superfamily Tumor necrosis factor receptor Molecular structure |
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