| CXCR4和VEGF-C在胃癌中的表达及与临床病理因素的关系 |
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| 引用本文： | 李利义,罗越,郑志强,徐斌,董剑达,韩绍伟. CXCR4和VEGF-C在胃癌中的表达及与临床病理因素的关系[J]. 医学研究杂志, 2011, 40(10): 85-88 |
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| 作者姓名： | 李利义 罗越 郑志强 徐斌 董剑达 韩绍伟 |
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| 作者单位： | 1. 325027,温州医学院附属第二医院普外科
2. 温州市瓯海区人民医院普外科 |
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| 基金项目： | 温州市科技计划基金，温州市瓯海区科技计划项目 |
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| 摘 要： | 目的通过检测趋化因子受体4(CXCR4)和血管内皮生长因子C(VEGF-C)在人胃癌组织中的表达,探讨其与胃癌临床病理因素的关系。方法应用免疫组织化学方法,检测CXCR4和VEGF-C在人胃癌组织中的表达,同时对其与胃癌临床病理因素的关系进行统计学分析。结果 CXCR4在胃癌组织中的阳性表达率为62%,其中无淋巴结转移组表达率为25%,淋巴结转移组表达率为73.68%,差异非常显著(P<0.01);无腹膜转移组表达率为(52.5%),显著低于腹膜转移组(100%)。VEGF-C在胃癌组织中的阳性表达率为72%。而且,CXCR4阳性表达与VEGF-C阳性表达呈显著正相关(К=0.597,P<0.01)。胃癌CXCR4和VEGF-C的表达水平与肿瘤的组织分化程度、肿瘤浸润深度、淋巴结转移及TNM分期密切相关(P<0.05)。结论 CXCR4和VEGF-C有望成为胃癌分子诊断和病期评估的标志之一。
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| 关 键 词： | CXCR4 VEGF-C 胃癌 临床病理因素 |
| 收稿时间： | 2011-03-02 |
| 修稿时间： | 2011-03-10 |
Relationship Between Expression of CXCR4 and VEGF-C in Gastric Cancer and Several Clinicopathological Factors |
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| Li Liyi,Luo Yue,Zheng Zhiqiang,Xu Bin,Dong Jianda,Han Shaowei. Relationship Between Expression of CXCR4 and VEGF-C in Gastric Cancer and Several Clinicopathological Factors[J]. Journal of Medical Research, 2011, 40(10): 85-88 |
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| Authors: | Li Liyi Luo Yue Zheng Zhiqiang Xu Bin Dong Jianda Han Shaowei |
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| Affiliation: | Li Liyi,Luo Yue,Zheng Zhiqiang,Xu Bin,Dong Jianda,Han Shaowei.Department of General Surgery,The Second Affiliated Hospital of Wenzhou Medical College,Zhejiang 325027,China |
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| Abstract: | Objective To investigate the relationship between expression of CXCR4 and VEGF-C in gastric cancer and several clinicopathological factors.Methods The expressions of CXCR4 and VEGF-C in 50 samples of human gastric cancer were detected by immuohistochemistry.The relationship between CXCR4 and VEGF-C expressions and the clinicopathological factors was statistically analyzed.Results The total positive rate of CXCR4 expression in these samples was 62%,and it was higher in the cases with lymphnode metastasis tha... |
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| Keywords: | Chemokine CXC receptor 4 Vascular endothelial growth factor C Gastric carcinoma Clinicopathological factors |
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