| 盐酸右美托咪定对开胸贲门癌根治术患者围术期应激反应的影响 |
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| 引用本文： | 程加文,谢英.盐酸右美托咪定对开胸贲门癌根治术患者围术期应激反应的影响[J].中国医药导报,2011,8(30):89-90,93. |
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| 作者姓名： | 程加文 谢英 |
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| 作者单位： | 江苏省淮安市仁慈医院(徐州医学院附属淮安医院)麻醉科,江苏淮安,223002 |
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| 摘 要： | 目的：观察全麻期间持续应用盐酸右美托咪定对开胸贲门癌根治术患者围术期应激反应的影响。方法：50例择期行开胸贲门癌根治术的患者,均采用全凭静脉麻醉,随机分为对照组和试验组（盐酸右美托咪定组）,每组各25例。监测两组麻醉诱导前（T0）、气管插管成功后即刻（T1）、手术开始30 min后（T2）、手术结束时（T3）、拔除气管导管后（T4）各时点血浆去甲肾上腺素（NE）、肾上腺素（E）浓度及平均动脉压（MAP）、心率（HR）,并记录患者咽喉反射恢复时间、自主呼吸恢复时间、拔管时间以及拔管后镇静评分。结果：与T0点相比,对照组在T1时点MAP和HR显著升高（P〈0.05）,T1～T4时血浆NE、E浓度显著升高（P〈0.05）;与T3点相比,对照组在T4时点MAP和HR显著升高（P〈0.05）;试验组在各时点均无明显变化,两组T1～T4各时间点对照组NE、E浓度高于试验组（P〈0.05）。结论：开胸贲门癌根治术围术期持续应用盐酸右美托咪定可有效抑制开胸贲门癌根治术患者围术期血浆NE、E浓度水平升高,血流动力学平稳,减轻围术期应激反应。
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| 关 键 词： | 盐酸右关托咪定 应激反应 去甲肾上腺素 肾上腺素 血流动力学 |
Perioperative stress response of Dexmedetomidine Hydrochloride to the patients with gush door cancer given radical surgery through thoracotomy |
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| CHENG Jiawen,XIE Ying.Perioperative stress response of Dexmedetomidine Hydrochloride to the patients with gush door cancer given radical surgery through thoracotomy[J].China Medical Herald,2011,8(30):89-90,93. |
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| Authors: | CHENG Jiawen XIE Ying |
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| Institution: | CHENG Jiawen,XIE Ying Department of Anesthesiology,Mercy Hospital of Huaian City(Huaian Hospital Affiliated to Xuzhou Medical College),Jiangsu Province,Huaian 223002,China |
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| Abstract: | Objective:To observe the perioperative stress response of Dexmedetomidine hydrochloride to the patients with gush door cancer given radical surgery through thoracotomy.Methods:50 patients with gush door cancer requiring radical surgery through thoracotomy were selected and randomly divided into control group and experimental group(Dexmedetomidine hydrochloride group),each group had 25 cases.The total intravenous anesthesia was used.The concentration of norepinephrine(NE),epinephrine(E) in plasma and mean ar... |
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| Keywords: | Dexmedetomidine hydrochloride Stress reaction Norepinephrine Adrenaline Hemodynamic |
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