醛固酮对靶器官心脏的损伤作用

醛固酮可由心脏及血管生成并在心血管系统的调节及多种心血管疾病的致病过程中起重要的作用,且独立于通过调节盐水平衡而介导的血压升高。醛固酮受体拮抗剂如螺内酯及依普利酮可以显著降低心力衰竭患者的发病率及病死率。醛固酮与盐皮质激素受体结合并通过多种机制造成靶器官心脏的损伤。心脏组织醛固酮与盐皮质激素受体结合有赖于11β-羟基类固醇脱氢酶2型的表达,且其心脏损伤与食盐摄入水平有关,新近研究显示醛固酮在心脏电重构中起重要作用。

Cardiac Injury Caused by Aldosterone

Aldosterone,which can be generated by the heart and blood vessels,also plays an important role in pathogenesis of several cardiovascular diseases,and the effect is independent from the elevation of blood pressure which is mediated by water and sodium regulation.Clinical studies show that aldosterone receptor antagonists such as spironolactone and eplerenone reduced the incidence of morbidity and mortality of patients with heart failure significantly.The combination of aldosterone and mineralocorticoid recep...