雷公藤多苷与环磷酰胺治疗肾病综合征的对比研究

目的：探究肾病综合征患者采用雷公藤多苷与环磷酰胺综合治疗的治疗效果和安全性。方法：选取2012年4月-2013年10月收治的74例肾病综合征患者进行治疗,随机分组,实验组44例患者采用雷公藤多苷的治疗,而对照组30患者仅使用环磷酰胺的治疗,对患者的治疗效果进行观察和评价。结果：实验组患者治疗的总有效率为88.64%,4例出现有不良反应,发生率为9.1%,24小时尿蛋白和血浆蛋白情况得到明显缓解;对照组患者治疗的总有效率为60.0%,10例出现有不良反应,发生率为33.3%。有显著的效果差异,有统计学意义（P〈0.05）。结论：肾病综合征患者选择雷公藤多苷治疗,可使肾功能得到较好的恢复,缓解身体症状,延缓病情的发展,且安全性较高,值得推荐

A Comparative Study of Tripterygium glycosides and cyclophosphamide treatment of nephrotic syndrome

Objective： To explore the use of nephrotic syndrome Tripterygium glycosides combined treatment with cyclophosphamide treatment effect and safety. Methods：April 2012 October 2013 were treated 74 cases of nephrotic syndrome treatment, randomized,44 patients in the experimental group using Tripterygium glycosides treatment , while the control group of 30 patients using only cyclophosphamide treatment, patient outcomes were observed and evaluated. Results：The total effective rate of patients treated with 88.64 % , 4 patients had adverse reactions , the rate was 9.1 %, 24- hour urine protein and plasma proteins significantly alleviate the situation;patients in the control group , the total effective rate was 60.0% 10 cases of adverse reactions , the rate was 33.3%. Have a significant effect difference was statistically significant （P 〈0.05）. Conclusion：Patients with nephrotic syndrome Tripterygium glycosides treatment choice,can get a better recovery of renal function, relieve physical symptoms, delay the development of the disease,and high security,is recommended.