培美曲塞二钠联合顺铂治疗二线晚期非小细胞肺癌的临床观察

目的探讨培美曲塞二钠联合顺铂方案一线治疗失败的晚期非小细胞肺癌的疗效和毒性。方法15例既往化疗或靶向治疗失败的晚期非小细胞肺癌患者接受培美曲塞二钠联合顺铂方案化疗,其中培美曲塞二钠500mg/m2加入0.9%氯化钠注射液100ml静脉点滴超过10min;顺铂75mg/m^2。每21d重复,2周期评价疗效。结果15例患者中,部分缓解（PR）1例,进展（SD）8例,PD6例,总有效率6.6%,毒性反应主要为疲乏无力,占53.3%。白细胞下降占46.6%,恶心、呕吐占33.3%。结论培美曲塞二钠联合顺铂方案是一线治疗失败的晚期非小细胞肺癌的理想方案之一。

Clinical observation of pemetrexed combined cisplaton AS second-line treatment for advanced NSCLC

Objective To investigate efficacy and toxicities of pemetrexed in combination with cisplaton in previously treated patients with NSCLC.Methods 15 patients of advanced NSCLC who had received targeted therapy or chemotherapy but had progressed,received treaty of pemetrexed 500 mg/m2,in 100 ml of 0.9%NACL,>10 min intervenous drip,cisplaton 75 mg/m2,every 21 days.to evaluate efficacy after 2 cycles.Results Of 15 patients,1patient was PR,8patients were SD,6 patients is PD,ORR were 6.6%.the main toxicities was fa...