In vitro effects of ciprofloxacin and roxithromycin on apoptosis of jurkat T lymphocytes |
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| Authors: | Jun Yong-Taek Kim Hee-Jung Song Min-Jin Lim Ji-Hyang Lee Dong-Gun Han Kyung-Ja Choi Su-Mi Yoo Jin-Hong Shin Wan-Shik Choi Jung-Hyun |
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| Institution: | Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea. |
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| Abstract: | Ciprofloxacin (CPFX) and roxithromycin (RXM) induced apoptosis of activated Jurkat T cells in vitro. CPFX showed concentration-dependent acceleration of apoptosis of activated Jurkat T cells by enhancing the expression of FasL and activities of caspase-3 and -8. RXM accelerated cell death, enhanced expression of FasL and caspase-3 but not caspase-8, and did not show the concentration dependency. |
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