HBV感染孕妇血清HBVM与TORCH抗体检测

目的了解ＨＢＶ感染孕妇血清ＨＢＶＭ与ＴＯＲＣＨ抗体阳性率。方法应用ＥＬＩＳＡ法筛查出９３例ＨＢＶ感染孕妇，并用ＰＣＲ检测ＨＢＶ－ＤＮＡ。分娩时取脐血测弓形体（Ｔｏｘ）、风疹病毒（ＲＶ）、巨细胞病毒（ＣＭＶ）、单纯疱疹病毒Ⅱ型（ＨＳＶ－Ⅱ）四种病原血清特异性ＩｇＭ和风疹病毒ＩｇＧ抗体。结果９３例ＨＢＶ感染孕妇中ＴＯＲＣＨ总感染率４７．３１％。单项抗体阳性率２５．８１％，７例为２项抗体阳性，２例３项抗体阳性。原发宫内感染以Ｔｏｘ最高（１２．９０％），ＣＭＶ次之（６．４５％），随后ＨＳＶ－Ⅱ（５．３８％），ＲＶ最低（３．２３％）。孕妇ＨＢｓＡｇ阳性组，ＰＣＲＨＢＶ－ＤＮＡ阳性率７６．９２％，ＴＯＲＣＨ感染率６１．５４％。ＨＢｓＡｇ阴性组，ＰＣＲＨＢＶ－ＤＮＡ阳性率３８．８９％，ＴＯＲＣＨ感染率３７．０４％。结论脐血ＴＯＲＣＨ感染率与母血ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢＶ－ＤＮＡ相关（相关系数分别为０．１４、０．２９、０．１５）。乙肝感染孕妇ＴＯＲＣＨ的抗体筛查对优生优育是非常有用的指标。

Examination of HBVM And TORCH antibody in HBV infected pregnant women

bjective To understand the prevalence of HBVM and TORCH antibodies in HBV infeeted pregnant women. Methods 93 HBV infected pregnant women were selected by using ELISA. They were also inspected for HBV - DNA with PCR.At time of their delivery cord blood were taken for special IgM to Tox,RV,CMV and HSV - and sera special IgG to RV. Results Pregnant women infected by HBV,the general infection rate of TORCH was 47.31%,25.81% cases were found with single Ab positive, 7 cases were found double Ab positive and 2 cases with three Ab positive. Tox had the highest primary intrauterine infection rate (12.90%).CMV had the second(6.45%).HSV - had the third(5.38%).RV had the lowest(3.23%).In the HBsAg positive group if was 76.92%,the infection rate of TORCH was 61.54%.In the HBsAg negetive group PCR HBV - DNA positive rate was 38.89%.TORCH was 37.04%. Conclusion The infection rate of TORCH of umbilical cord blood was related to HBsAg,HBeAg,HBV- DNA of maternal blood corelation coefficients were 0.14,0.29,0.15 respectively. So the screening for TORCH in pregnant women infected by HBV is a valuable method for eugenics.