婴幼儿边缘型维生素B_1缺乏症

目的探讨婴幼儿夜寐不安的原因及更有效地治疗夜寐不安的婴幼儿。方法对２５例以夜寐不安为主要表现，同时伴有烦躁、纳差的２岁以下小儿进行临床观察和红细胞转酮醇酶活力（ＴＰＰ效应）的测定。结果１６％的小儿属边缘型维生素Ｂ１缺乏，２０％属严重缺乏，而对照组小儿仅有６．７％属维生素Ｂ１缺乏症。经统计学处理，两组有显著差异（Ｐ＜０．０５）。实验组小儿经补充维生素Ｂ１１０ｍｇ１日３次口服１周后，临床症状明显好转的约占５０％，好转占３０％～４０％，而症状无改善的仅占１０％左右。治疗前ＴＰＰ效应异常者，经上述治疗后ＴＰＰ效应全部转为正常。结论口服补充维生素Ｂ１对治疗边缘型维生素Ｂ１缺乏症的效果是满意的。

Marginal vitamin B1 deficiency of infants and toddlers

Objectives To understand the reasons of sleeping problems in infants and toddlers and to treat it more effectively. Methods 25 children aged 02 years old whose main symptoms were sleeping problems, were given an clinical observation and detected by transketolase (TPP effect). Results 16% children had marginal vitamin B1 deficiency and 20% had severe vitamin B1 deficiency. While in control group only 6.7% children were vitamin B1 deficient. The difference between two groups were significant ( P <0.05). Children in testing group were prescribed by vitamin B1 10mg orally three times a day. After one week, 50% children's symptoms were improved obviously, and 30@% were improved. Only about 10% children's symptoms were not improved. All patients whose TPP effect were abnormal before treatment turned normal after treatment. Conclusion The effects of orally given vitamin B1 to marginal vitamin B1 deficient children were satisfactory.