发育迟缓儿童的功能性近红外光谱研究

目的 探讨发育迟缓儿童的功能性近红外光谱(fNIRS)特点,为发育迟缓儿童的脑功能分析提供参考依据。方法 2019年11日-2020年6月应用8通道功能性近红外光谱成像技术(fNIRS)检测13名发育迟缓儿童(发育迟缓组)和年龄、性别相匹配的19例健康儿童(正常组)的脑功能情况,采用独立样本t检验比较两组儿童各通道多尺度熵(MSE)及前额区MSE均值的差异。结果 发育迟缓组和正常组儿童前额区MSE均值分别为1.570±0.491、2.075±0.791,两组间差异具有统计学意义(t=2.228, P＝0.034)。两组儿童的MSE均值在3通道和8通道差异统计学意义(t＝2.513、2.868,P<0.01)。结论 发育迟缓儿童前额区自发脑信号的复杂性较正常健康儿童明显偏低,发育迟缓儿童存在前额叶双侧脑功能受损。

Functional near-infrared spectroscopy study in children with developmental delay

Objective To study the characteristics of children with developmental delay (DD) by using functional near infrared spectroscopy (fNIRS), so as to provide reference for the individual diagnosis and treatment of DD. Methods A total of 13 children with DD(DD group) and 19 normal children (NC group) were selected in this study, whose brain function was tested by 8-channel fNIRS. Multiscale entropy (MSE) of each channel and the mean MSE of the frontal region between DD group and NC group were compared by t test. Results The mean MSE of DD group (1.570±0.491) was significantly lower than that of NC group (2.075±0.791) (t=2.228, P＝0.034). The MSE values in channel 3 and 8 were significantly different between DD group and NC group(t=2.513, 2.868, P＜0.01). Conclusions Compared with the normal control group, the complexity of frontal lobe spontaneous brain signals in children with DD is significantly lower, indicating that children with DD have bilateral prefrontal brain function impairment.