TLRs信号通路和炎症因子的表达与反复呼吸道感染的关系分析

目的 研究Toll样受体(TLRs)信号通路和炎症因子的表达与反复呼吸道感染的关系,为临床治疗提供监测靶点.方法 将汕头市龙湖区第二人民医院儿科2019年1-12月门诊收治的150例反复呼吸道感染患儿纳入研究,记作病例组,另取同期于本院进行体检的健康儿童150例作为对照组.比较病变组和对照组儿童TLRs信号通路和炎症相...

Analysis of the relationship between the expression of TLRs signaling pathway and inflammatory factors and recurrent respiratory tract infection

Objective To study the relationship between Toll like receptor(TLRs)signaling pathway and expression of inflammatory factors and recurrent respiratory tract infection,in order to provide monitoring targets for clinical treatment.Methods A total of 150 children with recurrent respiratory tract infection treated in the Second People′s Hospital of Longhu District from January to December 2019 were included in this study and were selected as case group.Meanwhile,150 healthy children who took physical examination were selected as control group.Then the levels of TLRs signaling pathway,inflammatory related factors and oxidative stress related indexes were compared between the two groups.Results The levels of Toll like receptor 2(TLR2)and TLR4 in the case group were significantly higher than those in the control group(t=69.981,101.427,P<0.001).Additionally,the levels of serum interleukin-4(IL-4),interleukin-10(IL-10)and interferon gamma(INF-γ)in the case group were significantly higher than those in control group(t=78.453,63.388,116.697,P<0.001),while the level of tumor necrosis factor-α(TNF-α)was significantly lower in the case group(t=70.489,P<0.001).Pearson correlation analysis showed that the TLR2 and TLR4 levels were positively related to the levels of IL-4,IL-10 and TNF-α,but negatively correlated with INF-γlevels(P<0.05).The differences on superoxide dismutase(SOD),malondialdehyde(MDA)and catalase(CAT)between the case group and control group were significant(t=28.633,57.277,50.103,P<0.001).Conclusion The TLRs signaling pathway and inflammatory factors may be involved in the occurrence and development of recurrent respiratory tract infection,and children with recurrent respiratory tract infection apparently have abnormal oxidative stress.