基于眼动技术的高危孤独症谱系障碍幼儿限制性兴趣研究

目的 分析高危孤独症谱系障碍(HR-ASD)幼儿的局限兴趣眼动特征及行为指标间相关性,为ASD的亚型分类早期识别及干预提供依据.方法 选取2018年6月 2020年6月就诊于南方医科大学附属深圳妇幼保健院符合入组标准的年龄相匹配的ASD幼儿39例、HR-ASD幼儿49例及正常发育幼儿44例,采用SMI RED250便携...

Research on restrictive interest of high-risk children with autism spectrum disorder based on eye tracking technology

Objective To analyze the correlation between the characteristics of limited interest eye tracking and behavioral indicators of children with high-risk autism spectrum disorder(HR-ASD),so as to provide basis for early identification and intervention of subtypes of ASD. Methods From June 2018 to June 2020,children matched by age who met the criteria were enrolled in this study from Shenzhen Maternal & Child Health Care Hospital Affiliated to Southern Medical University,including 39 ASD children,49 HR-ASD children and 44 typical developed children.SMI RED250 portable eye tracking,Autism Observation Scale(ADOS)and Gesell development scale(GDS)were used to test the children.The results of eye tracking characteristics and behavioral indicators of the three groups were compared,and their correlation was analyzed. Results 1)For children in ASD group and HR-ASD group,the objects of interest for the first fixation were ships and table lamps,and the fixation track was irregular.While in typical developed children,the objects of interest for the first fixation were balloons,and the fixation track was regular.2)Children in ASD group and HR-ASD group had similar interest tendency,and the difference was statistically significant(F=123.01,89.32,P<0.01).Compared with typical developed children,children in ASD group and HR-ASD group had poor adaptability,fine motor,language and personal social skills(F=47.05,23.70,32.30,50.19,P<0.01).But there was no significant difference in general behavioral ability between ASD children and HR-ASD children(P>0.05).3)The eye tracking fixation time of ASD children and HR-ASD children was negatively correlated with language ability(r=-0.22,-0.43,P<0.05).The language ability of typical developed children was negatively correlated with their fixation on motor cars and swivel chairs(r=-0.17,-0.17,P<0.05),and their social interaction was positively related to their fixation on cakes(r=0.43,P<0.05). Conclusion Early recognition of the limited interest in high-risk ASD children is of great significance for early subtype classification,early auxiliary diagnosis and intervention of ASD.