学龄期肥胖儿童肺功能与血清25羟维生素D水平的相关性分析

目的 分析学龄期肥胖儿童的肺通气功能特征及与血清25羟维生素D[25-(OH)D]水平的相关性,探究维生素D对肥胖儿童肺功能的影响机制。方法 2019年1月-2020年1月期间,纳入104例6~12岁肥胖儿童,进行身高、体重测量,血清25-(OH)D检测及肺功能检查,比较维生素D缺乏、不足、适宜肥胖儿童的肺通气功能参数;采用多元线性回归分析血清25-(OH)D与肺功能参数的相关性。结果 轻中度肥胖组儿童各项肺功能参数均高于重度肥胖组,且FEF50%、MMEF的差异有统计学意义(t=2.808、2.164,P<0.05)。维生素D缺乏、不足和适宜组儿童FEV1、FVC、PEF、FEF25%、FEF50%、FEF75%的差异均具有统计学意义(F=3.988、4.758、3.142、5.186、3.478、3.220,P<0.05)。肺功能参数FEV1、FVC、PEF、FEF25%、FEF50%、FEF75%、MMEF与血清25-(OH)D水平呈线性正相关(B=0.341、0.315、0.371、0.745、0.665、0.715、0.613,P<0.05);FEV1/FVC、FEV1/FVC%与血清25-(OH)D之间未发现明显相关性。结论 血清维生素D水平与学龄期肥胖儿童的部分肺功能参数呈线性正相关,可能是肥胖儿童肺功能的保护性因素。

Correlation analysis of pulmonary function and serum 25-hydroxyvitamin D level in school-aged obese children

Objective To analyze the characteristics of pulmonary ventilation function in school-age obese children and its correlation with serum 25-hydroxyvitamin D[25-(OH)D],and to explore the mechanism of the effect of vitamin D on the pulmonary function of obese children.Methods Totally 104 obese children aged 6-12 years were recruited from January 2019 to January 2020 to measure their height,body mass,serum 25-(OH)D level and pulmonary ventilation function.Pulmonary ventilation function parameters were compared in obese children with deficient,insufficient and appropriate serum vitamin D level.Multiple linear regression was used to analyze the correlation between serum vitamin D and pulmonary function parameters.Results The lung function parameters in mild to moderate obesity group were higher than those in severe obesity group,and the differences in FEF50%and MMEF between the two groups was significant(t=2.808,2.164,P<0.05).The difference in FEV1,FVC,PEF,FEF25%,FEF50%and FEF75%were significant among obese children with deficient,insufficient and appropriate serum vitamin D level(F=3.988,4.758,3.142,5.186,3.478,3.220,P<0.05).Multiple linear regression showed that pulmonary function parameters FEV1,FVC,PEF,FEF25%,FEF50%,FEF75%and MMEF were positively linear correlated with serum 25-(OH)D level(B=0.341,0.315,0.371,0.745,0.665,0.715,0.613,P<0.05).Significant correlation was not found between FEV1/FVC,FEV1/FVC%and serum 25-(OH)D level.Conclusion There is a linear positive correlation between serum 25-(OH)D level and some lung function parameters of school-age obese children,which may be a protective factor of lung function of obese children.