超选择动脉内多种药物灌注介入治疗急性脑梗死

在我国,缺血性脑卒中是排在心血管病和肿瘤之后的第三位致死原因。虽然经过积极治疗后,大多数患者能够存活,但1/3将遗有严重功能障碍而另1/3需要某些康复治疗,增加了社会和家庭负担[1]。近年来,随着人们对急性脑梗死的损伤机制和临床治疗研究的深入,尤其是对缺血半暗带的研究不

Interventional therapy for acute brain infarction via superselective intra - arterial infusion of several thrombolytic drugs

Objective:To evaluate the clinical efficacy and safety of interventional thrombolysis therapy via superselective intra-arterial catheterization in the treatment of acute cerebral infarction and discuss drug dosage, infusion speed, treatment time, and related complications. Methods: Eight patients with acute cerebral infarction were infused with several kinds of thrombolytic drugs, such as urokinase, Xueshuantong, and dexamethasone, etc, via superselective intra-arterial catheterization within 24 h. Recanalization of occluded vessels was observed by angiography. Results: Vessel recanalization was complete in 2 out of 8 patients and partial in 4 patients. The total recanalization rate was 75%. It was absent in 2 patients. Three patients were cured. Three patients were substantially improved and 2 patients were partially improved. Conclusion: Interventional therapy using several kinds of thrombolytic drugs is effective and safe in the treatment of acute cerebral infarction. Earlier therapy is associated with better effects. Satisfactory effects can be obtained by controlling the drug dosage and the infusion speed in the limited time windows without increasing hemorrhage risk.