| 3型腺病毒基因组型与临床的研究 |
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| 引用本文： | 许忠,韩桂萱,傅文永,郑永晨,梁东,刘为民. 3型腺病毒基因组型与临床的研究[J]. 吉林大学学报(医学版), 1991, 0(6) |
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| 作者姓名： | 许忠 韩桂萱 傅文永 郑永晨 梁东 刘为民 |
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| 作者单位： | 白求恩医科大学第二临床医学院儿科(许忠，韩桂萱)，白求恩医科大学第一临床医学院儿科(傅文永，郑永晨，梁东)，白求恩医科大学第一临床医学院儿科(刘为民) |
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| 摘 要： | 用限制性内切酶对我国长春等5个地区引起婴幼儿肺炎的3型病毒(Ad_3)140株进行基因组型分析、分子流行病学特点及与临床致病的研究结果表明,我国5个地区14年间Ad_3有3个基因组型。我们命名为Ad_3Ⅰ、Ad_3Ⅱ和Ad_3Ⅲ。Ad_3Ⅰ是流行的优势基因组型。并证实一种优势基因组型是多种疾病的致病原。Ad_3流行高峰和年代出现变异株其毒力增强,通过与Ad_7优势基因型比较,揭示了3.7型腺病毒临床差异的实质。
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| 关 键 词： | 3型腺病毒 基因组型 临床特点 |
A STUDY ON GENOM AND CLINIC OF ADENOVIRUS TYPE 3 |
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| XU Zhong,et al. A STUDY ON GENOM AND CLINIC OF ADENOVIRUS TYPE 3[J]. Journal of Jilin University: Med Ed, 1991, 0(6) |
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| Authors: | XU Zhong et al |
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| Abstract: | We analysed 140 strains of adenovirus type 3 (Ad3) by using restriction endoneuclease BgL Ⅱ and BamH Ⅰ during 14 years (1976-1989) in Changchun, Shenyang, Beijing, Shanghai and Nangjing. Three genomes were identified in these five areas, and named Ad3 Ⅰ , Ad3 Ⅱ and Ad3 Ⅲ . Ad3 Ⅰ was the dominant genome in Ad3. During the period ot epidemic high peak, there would be variant strains of Ad3 with stronger pathogenicity and virulence. Through comparison , essentially, the clinical difference between adenovirus 3 and 7 was revealed on the molecular levels |
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| Keywords: | Ad3 Genome |
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