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The effect of drug holidays in an animal model of tardive dyskinesia
Authors:J. Bannet  R. H. Belmaker  R. P. Ebstein
Affiliation:(1) Dept. of Psychiatry, Hadassah-Hebrew University Hospital, Jerusalem, Israel;(2) The Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel
Abstract:Intermittent haloperidol treatment in mice increased 3H-spiroperidol binding to the same degree as continual haloperidol feeding. The results do not support the concept that drug holidays can reduce the incidence of tardive dyskinesia.
Keywords:Dopamine  Receptors  Haloperidol  Tardive dyskinesia
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